Knowhow offering
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| Title | Ranibizumab Biosimilar from CSIR- NCL |
| Knowhow is available for | A high-yield scalable method for producing refolded recombinant humanized Ranibizumab |
| Summary | |
| Advantages | UPSTREAM: Single fermentation batch required: Antibody fragment expression using duet vector system. High throughput refolding process : refolding yield of 40-45 %
DOWNSTREAM: Purification process of recombinant AbF from inclusion bodies
Novel multimodal chromatographic purification steps > 2X improvement in productivity
Purification platform applicable to: in-vitro refolded and soluble expressed antibody fragments
Overcomes requirement for affinity chromatography, a cost center; uses anion and cation exchange, reducing cost by 1/3rd
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Knowhow is listed under following categories
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Knowhow from
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| Scientific/ engineering subject areas |
Life sciences/ biosciences & engineering |
| Investor interest categories |
Biotechnology/ Biomedical/ Health Technologies |
| Industries |
Pharmaceuticals, Bulk Drugs, Formulations |
| Customer categories and nature of business |
Businesses and other industries (B2B) |
| Technology readiness levels
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TRL B: Proof-of-concept demonstrated in lab scale |
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Related documents:
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(Local uploaded copy)
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Database reference
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| Database record number |
20220110015620 |
| Date of upload |
10 / Jan / 2022 |
| Date of update |
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| URL to site when communicating about this knowhow |
http://techex.in/khdb/viewrecord.php?recordno=20220110015620 |
| Request for this technology |
Click here for Request Form |
